Vismodegib-resistant basal cell carcinomas in basal cell nevus syndrome: Clinical approach and genetic analysis
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چکیده
منابع مشابه
Acrochordon-like basal cell carcinomas in patients with basal cell nevus syndrome.
Basal cell nevus syndrome is an autosomal dominant disorder characterized by multiple basal cell carcinomas, along with numerous other documented clinical features. Acrochordons (or skin tags) are common benign neoplasms that are appropriately left untreated in most patients. We describe two patients with known BCNS who were found to have multiple BCCs that clinically resembled acrochordons. Ou...
متن کاملValue of CD10 Expression in Differentiating Cutaneous Basal from Squamous Cell Carcinomas and Basal Cell Carcinoma from Trichoepithelioma
Background: In addition to the well-defined histological criteria for squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), immunohistochemical techniques can be used in difficult cases for their differentiation. As differential diagnosis between trichoepithelioma (TE) and BCC is sometimes difficult for the clinician and the pathologist, CD10 may be a useful marker for definite diagnosi...
متن کاملMeningeal calcification in basal cell nevus syndrome.
To cite: Nair PP, Khilari M, Peddawad D, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013200545 DESCRIPTION A 20-year-old woman presented with history of headache for 1 year. The headaches were mild to moderate in intensity, bilateral and non-throbbing, with no symptoms suggestive of raised intracranial pressure. The patient had hyperpigmented skin lesi...
متن کامل[A case of basal cell nevus syndrome].
A case of basal cell nevus syndrome is reported. The patient, a 25-year-old man, had no family history of this condition. The patient showed multiple mandibular cysts, calcification of the falx cerebri, bridging of the sella turcica, ocular hypertelorimsm, a broad nasal root, and pitting of the palms. These findings correlate with reports in the literature and permitted the diagnosis of basal c...
متن کاملThe use of vismodegib to shrink keratocystic odontogenic tumors in patients with basal cell nevus syndrome.
IMPORTANCE Keratocystic odontogenic tumors (KCOTs) of the jaw affect more than 65% of patients with basal cell nevus syndrome (BCNS). Surgery frequently causes facial disfigurement and is not always curative. Most BCNS-related and some sporadic KCOTs have malignant activation of the Hedgehog signaling pathway. OBSERVATIONS We examined the effect of vismodegib (an oral Hedgehog pathway inhibit...
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ژورنال
عنوان ژورنال: JAAD Case Reports
سال: 2018
ISSN: 2352-5126
DOI: 10.1016/j.jdcr.2017.11.011